A study was conducted to assess the abilities of different
drugs to inhibit the effect of a chemical called TNF in cell sheets
taken from the kidneys of pigs. TNF causes the junctions between cells
to open, and the purpose of the study was to identify drugs that might
prevent TNF from opening the junctions.
Forskolin was one of the drugs that was studied.
TNF causes the seals between cells to open, allowing fluid and chemicals to
flow through the cell sheet. Forskolin is supposed to reseal the junctions
between the cells, inhibiting the flow of fluid and chemicals.
A Control group of cell sheets with no TNF added was used to establish a
baseline measure of the effect of Forskolin alone.
The accompanying dataset contains the results of two experiments on the ability
of Forskolin to overcome the effect of TNF.
The variables in the dataset include:
- Group Type (Control or TNF present)
- Dose Level of Forskolin
- Experiment (A or B)
- PctRes (Percentage of Initial Resistance measured for the cell sheet)