Favorite Datasets from Early (and Late) Phases of Drug Research

Sister Chromatid Exchange (SCE) Study in Mice

Part 4 - Table 4


Four mice from each sex were assigned randomly to each of four treatment groups including a negative control (saline; S) and three graded doses (D1: 59/59, D2: 197/197, D3: 590/590 mg/kg) of a combination drug product. Two additional animals from each sex were randomized to be treated with a positive control (P). Bone marrow cells from each animal were prepared and examined for sister chromatid exchanges (SCE's). For each animal, the total number of SCE's in 25 mitotic cells was recorded.

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Part 4 - Table 4
Sister Chromatid Exchange (SCE) Study in Mice
Total Number of Sister Chromatid Exchanges
Males Females
Drug (mg/kg) Drug (mg/kg)
S 59 197 590 P S 59 197 590 P
114 132 107 80 547 132 179 164 139 392
164 132 161 115 778 143 179 164 151 679
175 177 163 145 154 181 182 157
414 222 213 175 190 209 (a) 171

(a) animal died


Source:

Bradstreet, T.E. and Liss, C.L. (1995) "Favorite Data Sets from Early (and Late) Phases of Drug Research - Part 4." Proceedings of the Section on Statistical Education of the American Statistical Association.

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Last modified July 24, 1997 - THS