Favorite Datasets from Early Phases of Drug Research

Pharmacokinetic Study of Carbidopa

Part 2 - Table 6


As part of a pharmacokinetic study, 12 healthy male subjects were allocated randomly to a three period crossover design receiving one of three graded doses (25, 50, 100 mg) of Carbidopa q8h in each treatment period. A seven day washout period separated the treatment periods. The pharmacokinetic variables AUC, Cmax, and Tmax were calculated for each subject from plasma concentrations assayed from blood samples taken at 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, and 8 hours postdosing following the second dose of carbidopa on the sixth day of each treatment period.

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Part 2 - Table 6
Pharmacokinetic Study of Carbidopa
Dose (mg) AUC (ng*hr/ml) Cmax (ng/ml) Tmax (hours)
Sub I II III I II III I II III I II III
1 100 25 50 604.0 240.4 364.6 137.0 61.1 95.3 1.5 2.0 1.0
2 25 50 100 139.7 352.9 1086.6 44.4 101.0 225.0 1.0 1.0 2.0
3 50 100 25 386.0 766.1 190.8 86.6 204.0 44.6 1.5 1.0 1.5
4 50 100 25 174.7 878.2 148.0 46.4 245.0 53.8 1.5 2.0 1.0
5 50 25 100 604.9 140.6 668.3 194.0 29.7 143.0 0.5 2.0 1.0
6 25 100 50 168.7 835.8 355.6 44.9 223.0 90.6 1.0 1.0 1.5
7 100 50 25 1004.6 264.0 123.9 318.0 81.2 55.0 1.0 0.5 1.0
8 25 100 50 114.1 475.1 369.9 29.0 137.0 86.3 1.0 1.0 1.0
9 50 25 100 541.5 336.4 1533.0 119.0 86.8 399.0 2.0 1.0 1.5
10 25 50 100 222.0 404.3 917.3 58.4 105.0 231.0 2.0 3.0 3.0
11 100 50 25 885.3 299.4 76.5 208.0 74.2 25.0 2.0 1.5 0.5
12 100 25 50 1042.9 116.0 169.6 259.0 29.6 49.8 1.5 2.0 1.0

I, II, III = Study Periods I, II, III, respectively


Source:

Bradstreet, T.E. (1992) "Favorite Data Sets from Early Phases of Drug Research - Part 2." Proceedings of the Section on Statistical Education of the American Statistical Association.

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Last modified July 14, 1997 - THS